Evaluation of pharmacological mechanisms of antinociceptive effect of Teucrium polium on visceral pain in mice

Authors

  • A. Bashiri Dezfouli DVM Student, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • M. Jadidoleslami Graduated from Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • M. Taati Department of Pathobiology, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran
  • M. Zendehdel Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Abstract:

Teucrium polium is used for treatment of visceral pain in Iranian folkloric medicine. In this studyantinociceptive mechanisms of T. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male NMRI mice. To reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic antagonists on extract-induced antinociception. The results of this study showed that pretreatment with naloxone,chlorpheniramine and cimetidine significantly attenuate the antinociceptive effect of the extract. However,cyproheptadine and phentolamine had no effect. Our results clearly show antinociceptive effects of T. poliummay be mediated by opioidergic and histaminegic H1 and H2 receptors.

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evaluation of pharmacological mechanisms of antinociceptive effect of teucrium polium on visceral pain in mice

teucrium polium is used for treatment of visceral pain in iranian folkloric medicine. in this studyantinociceptive mechanisms of t. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male nmri mice. to reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic...

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Journal title

volume 12  issue 4

pages  292- 297

publication date 2011-12-20

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